 |
|
 |
|
|
|
|
 |
Now that
tigecycline is being used, what do you think of it? If the microbiology
indicates that the bacteria is only sensitive to one of the tetracycline
(ie minocycline), would you conclude that it's sensitive to
tigecycline? If that's the case, which one would you recommend to use,
tigecycline or tetracycline?
I appreciate your comments.
|
 |
Tygecycline is a new broad spectrum drug which is beginning to be used in the treatment of skin and soft tissue infections. It has activity against a wide variety of enterics, anaerobes and staph (including MRSA). Tygecycline is not affected by the two major tetracycline resistance mechanisms (ribosomal protection and drug efflux) so it is much more active than tetra, doxy or mino. It is not recommended to test tygecycline in place of older tetracyclines, but in addition for fear that Docs may assume any tetracycline could be used if a "S" result for tygecycline was reported. Labs generally test the least active drug in the class such as tetracycline against gram negatives. A "S" bug to tetra would be considered "S" to all other tetracycline class drugs. If the isolate is reported as "R" to tetra, about 10% may be "S" to doxy or mino. I believe a higher % will be sensitive to tygecycline. For Staph, most are sensitive to doxy/mino (>95%) and resistance to tygecycline has not been reported to any great extent. You don't want to encourage tygecycline use by testing in place of doxy/mino because of cost issues. Doxy/mino are cheap and just as effective in treating SST infections.
DISCLAIMER
Askit is for general information purposes only and may not be relied upon by users for decisions or action in specific circumstances. Neither ASM nor the expert assures the accuracy or completeness of information provided. Questions are answered based on current information, which may change over time. Please note the date that a question was answered. If an answer is more than one year old, you may want to resubmit the question for an updated answer.
The advice and comments do not necessarily reflect the views of ASM. ASM and INDIVIDUAL experts expressly disclaim any and all liability for any direct, indirect, or special damages or loss of any nature incurred as a consequence of use of this site or any advice or comment by any expert. By using Askit, the user accepts the waiver of claims and all terms of use of ASM’s site, including the disclaimers set forth in the “Legal Rights” link on ASM’s home page.
|
| |
|
Return to Questions
|
|
|
|
 |
|
|
