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Susceptibility testing should be performed on coagulase-negative staphylococci whenever the organism appears to be clinically significant. Sometimes this can be difficult to establish. Routinely, susceptibility testing should be performed on coagulase-negative staphylococcal isolates from sterile body sites. In the case of blood culture isolates, multiple sets growing coagulase-negative staphylococci should have susceptibility testing performed. Coagulase-negative staphylococcal isolates from sternal wounds are frequently significant isolates and warrant susceptibility testing. Additionally, we perform susceptibility testing on coagulase-negative staphylococci isolated from wound cultures when staph was seen in the direct gram stain and S. aureus was not isolated. This is a general overview of the topic and is not meant to be exhaustive review.
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