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Is it unusual or not possible for Proteus mirabilis to be resistant to Cefoxitin? When a pure isolate tests as resistant is it appropriate to report as resistant?
It is indeed possible for P. mirabilis to be resistant to cefoxitin. The isolate may have a plasmid-mediated AmpC-type beta-lactamase. Yes, the isolate should be reported as cefoxitin resistant. See the following reference: Philippon,A., G Arlet, and GA Jacoby. 2002. (Minireview) Plasmid-determined AmpC-type beta-lactamases. Antimicrob Agents Chemother. 46:1-11. DISCLAIMER Askit is for general information purposes only and may not be relied upon by users for decisions or action in specific circumstances. Neither ASM nor the expert assures the accuracy or completeness of information provided. Questions are answered based on current information, which may change over time. Please note the date that a question was answered. If an answer is more than one year old, you may want to resubmit the question for an updated answer. The advice and comments do not necessarily reflect the views of ASM. ASM and INDIVIDUAL experts expressly disclaim any and all liability for any direct, indirect, or special damages or loss of any nature incurred as a consequence of use of this site or any advice or comment by any expert. By using Askit, the user accepts the waiver of claims and all terms of use of ASM’s site, including the disclaimers set forth in the “Legal Rights” link on ASM’s home page.
 
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