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Group B strep is part of the endogenous vaginal/rectal flora in 20% of women. Screening is recommended only for pregnant women at 35-37 wk gestation in order to determine if the fetus is at risk. Women with DIV (desquamative inflamatory vaginitis) usually respond to clinamycin treatment and GBS has been associate with SOME of these infections, but that is an uncommon diagnosis that should not be considered routinely.
Enterobacteriaceae, including E. coli, are also endogenous vaginal flora in about 20% of women. It is not considered an agent of vaginitis or vaginosis,
The underlying issue in this question is the appropriateness of high vaginal cultures. The only 3 diagnoses that should be routinely sought in women with ovarian function (after menarche and before monopause) are yeast vaginitis, trichomoniasis and BV. Culture is recommended only for the first two and not BV.
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