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I am not aware of any published guidelines specific for your question. Your best resource is the medical staff of your institution, especially Infectious Diseases specialists. Commercial labs may obtain advice from their stakeholders.
Multiple specimens may be collected on the same day from similar sources (usually from a surgical procedure). Similar collections (e.g. bone, joint, and associated tissue) generally would not need susceptibility testing from every specimen if the same organism is isolated from each source. Perform the susceptibility test on one source, and refer the others to that specimen.
A different example, however, would be if an enteric gram negative rod is isolated from the blood as well as from a urine specimen collected the same day. In this case it may be appropriate to perform susceptibility testing from each source, since a different battery of antimicrobial agents would be reported for each specimen source.
Of course, multiple specimens received for detection of MRSA colonization would require some sort of susceptiblity test to determine whether the isolate is a MRSA or not.
We hope that we were able to answer your question.
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