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my clinician had send my lab blood culture and urine culture from a pt. who hhad h/o fever three days and uti symptoms. urine showed pyuria and grew candida spp where as blood culture grew e.coli sensitive to ceftriaxone. now clinician is asking he was suspecting uti so why did urine culture despite pyuria did not grow e.coli? second what is the relivance of e.coli in blood when pt. is not showing any signs of sepsis other than fever. at the same time he admits that pt. was put on hrs.ceftriaxone to which pt. responded in 48 hrs. pl answer this.
Thanks for your interest in ASM's Askit. This question contains more for a clinician to answer than a laboratorian. The laboratory issues are: 1) Can Candida cause UTI with pyuria? Yes. The E. coli could be from some other infectious process. 2) Why E. coli in the blood and yeast in the urine? If the patient has severe, bacteremic urinary tract with E. coli, it may be that the Candida overgrew the GNR. It may be that the patient has a blockage (tumor, stones, etc.) and the E. coli is unable to reach the bladder. It may be that antimicrobials were administered before the specimen was collected and sterilized the urine very quickly. I suggest performeing a gram stain of the original urine to see if GNR's are present but did not grow. 3) Why no signs or symptoms (although patient did have fever) of bacteremic disease? Elderly patients or patients that are immune compromised show very few signs/symptoms even with serious infections. These should address some of your concerns. My best advice, review a direct gram stain, make sure the patient is not also infected at a site other than the urinary tract, and check for stones or other blockage. Good luck. We hope that we were able to answer your question. Please visit us again at the American Society for Microbiology. DISCLAIMER Askit is for general information purposes only and may not be relied upon by users for decisions or action in specific circumstances. Neither ASM nor the expert assures the accuracy or completeness of information provided. Questions are answered based on current information, which may change over time. Please note the date that a question was answered. If an answer is more than one year old, you may want to resubmit the question for an updated answer. The advice and comments do not necessarily reflect the views of ASM. ASM and INDIVIDUAL experts expressly disclaim any and all liability for any direct, indirect, or special damages or loss of any nature incurred as a consequence of use of this site or any advice or comment by any expert. By using Askit, the user accepts the waiver of claims and all terms of use of ASM’s site, including the disclaimers set forth in the “Legal Rights” link on ASM’s home page.
 
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